Organic field effect transistors based on multilayers of self-assembled biological systems covered by an organic semiconductor layer: processes for their realization and use as sensors

SCHEDA BREVETTO

Abstract:

Transistor comprising at least one conductive layer, at least one dielectric layer and at least one thin organic semiconductor film and characterized by at least one layer of biological material deposited directly on the surface of the dielectric. Said layer of biological material is constituted by single or double layers of phospholipids, layers made of proteins such as receptors, antibodies, ionic channels and enzymes, single or double layers of phospholipids with inclusion or anchoring of proteins such as: receptors, antibodies, ionic channels and enzymes, layers made of oligonucleotide (DNA, RNA, PNA) probes, layers made of cells or viruses, layers made of synthetic receptors for example molecules or macromolecules similar to biological receptors for properties, reactivity or steric aspects.

Advantages:

Furthermore, the bilayer architecture OFET sensor, recently proposed, appears to be of great interest for high performance analysis of chiral analytes.
The main advantages are: OFET sensors allow label-free detection; in fact it is not necessary to label the sample by attaching fluorescent or electroactive markers to the species to be analyzed; single devices, as well as matrix systems (array), arc miniaturizable and realizable with low cost screen-printing technologies and on substrates made of plastic, paper or even Fabrics; they do not need a reference electrode to measure the current changes induced by the interaction with the species to he detected.
[0007] These and other advantages will be better highlighted in the detailed description of the invention which specifically refers to tables 1/4, Fig. figures 1 to 8, in which an example absolutely not limiting of a preferred realization of the present finding is exposed.
Of course, the analytical systems for such applications must be easy to use and provide easily readable outputs/responses and quantitative data.
However, a lot of presently developed biosensors present several disadvantages in terms of cost, reagents availability, regeneration and reproducibility.
Water electrolysis and high ionic analyte conductivity represent, indeed, the main drawbacks to overcome for applications in an aqueous environment.

Application field:

INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES

BASIC ELECTRIC ELEMENTS

Technical board:

The object of the present invention consists of innovative methods for realizing organic field effect transistors (OFET) comprising layers of sell-assembled biological systems as integral part of the active material. Further, the present invention relates to the use of said OFET as label-free, selective and sensitive sensors for detecting volatile or liquid substances for example of interest in biomedical field.
All devices object of the present invention can function as electronic sensors and can be realized by techniques developed in the framework of organic electronics.

iccom2[1]

Patent Title

Organic field effect transistors based on multilayers of self-assembled biological systems covered by an organic semiconductor layer: processes for their realization and use as sensors

Other Title

Inventor(s)

TORSI LUISA

PALAZZO GERARDO

CIOFFI NICOLA

ANGIONE MARIA DANIELA

MAGLIULO MARIA

COTRONE SERAFINA

SCAMARCIO GAETANO

SABBATINI LUIGIA

MALLARDI ANTONIA

Published As

Publ. number Pub. date Appl. number
Appl. date
Publ. Stage
EP2385563 20111109
2010EP-0425146
20100503
A1 – Application published with search report

NsRIF

— Catalogo brevetti CNR

Country of validity

EP

Ownership

CNR (11.1%)

Università degli Studi di Bari (88.9%)

Contacts

info@ilo-puglia.cnr.it