SCHEDA BREVETTO

Abstract:

Transistor comprising at least one conductive layer (4), at least one gate dielectric layer (3) and at least one semiconducting film (1) deposited on top of a receptor molecule layer (2) previously deposited or covalently linked to the surface of the gate dielectric (3). Said layer of biological material is constituted by single or double layers of phospholipids, layers made of proteins such as receptors, antibodies, ionic channels and enzymes, single or double layers of phospholipids with inclusion or anchoring of proteins such as: receptors, antibodies, ionic channels and enzymes, layers made of oligonucleotide (DNA, RNA, PNA) probes, layers made of cells or viruses, layers made of synthetic receptors for example molecules or macromolecules similar to biological receptors for properties, reactivity or steric aspects.

Advantages:

Furthermore, the bilayer architecture FET sensor, recently proposed, appears to be of great interest for high performance analysis of chiral analytes [L.
The major advantage is that such a configuration allows a intimate contact between the recognition bio-layer and the two dimensional charge transport occurring in the FET incrementing, as it will be shown further on, by orders of magnitude the device sensitivity.
The main advantages are: The analytical systems for such applications must be easy to use and capable to provide easily readable outputs/responses as well as quantitative data. However, a lot of up to date developed biosensors present disadvantages in terms of cost, reagents availability, regeneration and reproducibility. Water electrolysis and high ionic analyte conductivity represent, indeed, the main drawbacks to overcome for applications in an aqueous environment.

Application field:

INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES

Technical board:

The object of the present invention consists of innovative methods for realizing field-effect transistors (FET) comprising layers of self-assembled biological systems deposited underneath the semiconductive electronic active material. Furthermore, the present invention relates to the use of said FET devices as label- free, selective and ultra-sensitive sensors for detecting volatile or liquid substances for example of interest, but not limited to, the biomedical field.
All devices object of the present invention can function as electronic sensors and can be realized by techniques developed in the framework of flexible or organic electronics.